Moroctocog alfa
ReFacto (moroctocog alfa) is a protein pharmaceutical. Moroctocog alfa was first approved as Refacto af on 1999-04-13. It has been approved in Europe to treat hemophilia a.
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Brand Name | Status | Last Update |
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| xyntha | Biologic Licensing Application | 2010-08-31 |
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374 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemophilia a | D006467 | EFO_0007267 | D66 | 44 | 36 | 108 | 50 | 114 | 329 |
| Hemophilia b | D002836 | — | D67 | 2 | 2 | 11 | 1 | 11 | 26 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | 5 | 1 | 7 | 3 | 8 | 23 |
| Hemostatic disorders | D020141 | — | — | 5 | 1 | 7 | 3 | 8 | 23 |
| Von willebrand diseases | D014842 | EFO_0003910 | D68.0 | 1 | 2 | 13 | 3 | 2 | 20 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | 4 | 3 | 3 | 10 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | 1 | 1 | 2 | 2 | 6 |
| Inherited blood coagulation disorders | D025861 | — | — | — | — | — | 1 | 3 | 4 |
| Recurrence | D012008 | — | — | — | — | — | 1 | 2 | 3 |
| Immune tolerance | D007108 | — | — | — | — | — | 1 | — | 1 |
Show 3 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Deficiency diseases | D003677 | EFO_1001067 | E63 | — | — | 1 | — | 1 | 2 |
| Hemorrhagic disorders | D006474 | — | D69.9 | — | — | 1 | — | 1 | 2 |
| Bone diseases | D001847 | — | M89.9 | — | — | 1 | — | — | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | 1 | — | — | — | 5 |
| Sclerosis | D012598 | — | — | — | 1 | — | — | 3 | 4 |
| Genetic therapy | D015316 | — | — | 1 | 1 | — | — | 1 | 2 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34.0 | — | 1 | — | — | — | 1 |
| Diffuse scleroderma | D045743 | EFO_0000404 | — | — | 1 | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 3 von willebrand disease | D056729 | Orphanet_166096 | D68.03 | 1 | — | — | — | 1 | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | — | 3 | 3 |
| Joint diseases | D007592 | HP_0003040 | M12.9 | — | — | — | — | 2 | 2 |
| Coagulation protein disorders | D020147 | — | — | — | — | — | — | 2 | 2 |
| Infertility | D007246 | HP_0000789 | — | — | — | — | — | 2 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
| Seroma | D049291 | — | — | — | — | — | — | 1 | 1 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | — | — | 1 | 1 |
| Replacement arthroplasty | D019643 | — | — | — | — | — | — | 1 | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 1 | 1 |
| Hemolysis | D006461 | — | — | — | — | — | — | 1 | 1 |
Show 38 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Moroctocog alfa |
| INN | moroctocog alfa |
| Description | Moroctocog alfa (trade name ReFacto in the EU) is a recombinant antihemophilic factor genetically engineered from Chinese hamster ovary (CHO) cell line. Chemically it is a glycoprotein. It is manufactured by Genetics Institute, Inc. and used to control and prevent hemorrhagic bleeding and prophylaxis associated with surgery or to reduce the number of spontaneous bleeding episodes in patients with hemophilia A. It is partially a recombinant coagulation factor VIII since it has an amino acid sequence which compares to the 90 + 80 kDa form of factor VIII (BDDrFVIII). It also has posttranslational modifications which are similar to those of the plasma-derived molecule. It can not prevent hemorrhagic bleeding associated with von Willebrand's disease since it is not a von Willebrand factor.
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| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109137 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB13999 |
| UNII ID | 113E3Z3CJJ (ChemIDplus, GSRS) |
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Refacto – Pfizer
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2,595 adverse events reported
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